Matthew Aronoff

Assistant Professor

Photo: Matthew Aronoff
Clark Hall 213

Research Area/s:

Chemical Biology and Biochemistry,  Organic Chemistry


  • B.A. Liberal Arts, 2003, St. John’s College, Santa Fe, New Mexico
  • B.S. Chemistry, 2011, Fort Lewis College, Durango, Colorado
  • Ph.D. Chemistry, 2015, University of Wisconsin–Madison
  • Postdoctoral Fellow, 2016-2022, ETH Zurich, Zurich, Switzerland


Post-translational modifications (PTMs) are essential chemical changes that modulate the structure and function of peptides and proteins. Often these modifications become dysregulated in major diseases including cancer, diabetes, or neurodegenerative disorders, but as these protein modifications transcend the genome, they are difficult to study using traditional biological methods. To address this challenge, our research leverages chemical approaches to investigate the molecular roles of post-translational modifications in disease. In this manner we combine organic synthesis with the cross-disciplinary techniques of chemical biology to develop innovative and creative chemical tools and novel techniques to synthesize and study PTMs of peptides and proteins. Our goal is to advance our collective understanding of PTMs, and ultimately provide new starting points for therapeutics.

Selected Publications

  • Aronoff, M. R.; Hiebert, P.; Hentzen, N. B.; Werner, S.; Wennemers, H., Imaging and Targeting LOX-Mediated Tissue Remodeling with a Reactive Collagen Peptide. Nat. Chem. Biol. 202117, 865-871.
  • Aronoff, M. R.; Egli, J.; Menichelli, M.; Wennemers, H., γ-Azaproline Confers pH‑Responsiveness and Functionalizability on Collagen Triple Helices. Angew. Chem. Int. Ed. 2019, 58,3143-3146.
  • Andersen, K. A.*Aronoff, M. R.*; McGrath, N. A.; Raines, R. T., Diazo Groups Endure Metabolism and Enable Chemoselectivity in CelluloJ. Am. Chem Soc. 2015137, 2412-2415.
  • Aronoff, M. R.; VanVeller, B.; Raines, R. T., Detection of Boronic Acids through Excited-State Intramolecular Proton-Transfer Fluorescence. Org. Lett. 201315, 5382-5385.
  • Aronoff, M. R.; Bourjaily, N. A.; Miller, K. A., A Concise, Protecting Group Free Total Syntheses of (+) Sattabacin and (+)-4-Hydroxysattabacin. Tetrahedron Lett201051, 6375-6377.
  • ; Bourjaily, N. A.; Miller, K. A., Concise, Protecting Group Free Total Syntheses of (+) Sattabacin and (+)-4-Hydroxysattabacin. Tetrahedron Lett. 2010, 51, 6375-6377.