Achraf Noureddine

Assistant Professor

Photo: Achraf Noureddine
Email: 
anoureddine@unm.edu
Office: 
Clark Hall 210B

Research Area/s:

Chemical Biology and Biochemistry,  Materials Chemistry,  Organic Chemistry

Research Interests:

  • Targeted Nanomedicine
  • Cell-Material Hybrids
  • Programmable Theraputics
  • Nanoparticles
  • Sol-Gel

Lab website: coming soon

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Education

Ph.D. Ecole Nationale Supérieure de Chimie de Montpellier, FR, Chemical and Nano-Engineering, 2014

M.Sc. University of Lille (France) Chemical Processes Engineering, 2011

B.Sc. University of Lille (France) Chemistry, 2009

The Nanoscience and Programmable Theranostics Research Lab

At the intersection of chemistry and biomedical engineering, the Noureddine research group aims at developing programmable nanotheranostics designed to improve the delivery, efficacy, and safety of therapeutics. We engineer silica-based nanoparticles, lipid-inorganic hybrid systems, metal-biomolecular assemblies, and other functional nanomaterials to control where and when therapeutic agents act in the body. By combining materials chemistry with biomedical engineering, our approach aims to address key limitations of conventional therapeutics, including poor tissue targeting, short biological half-life, off-target effects, and dose-limiting toxicity. We are particularly interested in translating these platforms toward targeted and long-acting delivery of therapeutic molecules, including applications in oncology, metabolic disease, and genetic/rare diseases.

Teaching

Organic Chemistry II CHEM 302

Analytical Instrumentation: Theory and Application CHEM 453L

Synthesis of Nanostructures CHEM 471, CHEM 545, NSME 518

Selected Publications

In Gene Delivery:

1. Noureddine, A.; Maestas-Olguin, A.; Saada, E. A.; LaBauve, A. E.; Agola, J. O.; Baty, K. E.; Howard, T.; Sabo, J. K.; Espinoza, C. R. S.; Doudna, J. A.; Schoeniger, J. S.; Butler, K. S.; Negrete, O. A.; Brinker, C. J.; Serda, R. E., Engineering of monosized lipid-coated mesoporous silica nanoparticles for CRISPR delivery. Acta Biomater 2020.
2. Maestas-Olguin, A.; Olewine, M.; Thabata, S.; Tsala Ebode, J.; Arcos, M.; Krawchuck, J.; Coker, E. N.; Brearley, A. J.; Xue, X.; Watt, J.; Noureddine, A.*; Brinker, C. J., Metallic Cation-Mediated Entrapment of Nucleic Acids on Mesoporous Silica Surface: Application in Castration-Resistant Prostate Cancer. Chemistry of Materials 2023, 35 (24), 10371-10383.
Mesoporous Silica Surface: Application in Castration-Resistant Prostate Cancer. Chemistry of Materials 2023, 35 (24), 10371-10383.

 

In Materials Design:

3. Noureddine, A. *; Maestas-Olguin, A.; Tang, L.; Corman-Hijar, J. I.; Olewine, M.; Krawchuck, J. A.; Tsala Ebode, J.; Edeh, C.; Dang, C.; Negrete, O. A.; Watt, J.; Howard, T.; Coker, E. N.; Guo, J.; Brinker, C. J., Future of Mesoporous Silica Nanoparticles in Nanomedicine: Protocol for Reproducible Synthesis, Characterization, Lipid Coating, and Loading of Therapeutics (Chemotherapeutic, Proteins, siRNA and mRNA). ACS Nano 2023, 17 (17), 16308-16325.
4. Guo, J.; Amini, S.; Lei, Q.; Ping, Y.; Agola, J. O.; Wang, L.; Zhou, L.; Cao, J.; Franco, S.; Noureddine, A.; Miserez, A.; Zhu, W.; Brinker, C. J., Robust and Long-Term Cellular Protein and Enzymatic Activity Preservation in Biomineralized Mammalian Cells. ACS Nano 2022, 16 (2), 2164-2175.

 

 In Cancer Immunotherapy:

5. Tang L., Marwedel B., Dang C., Olewine M., Medina LY., Naydenkov P., Gayoso V., Howard T., Watt, J., Dogra P., Serda RE*, Noureddine A.* Rational Design of Immunogenic Nanoparticles as a Platform for Enhanced Ovarian Cancer Immunotherapy in Mice via Macrophage Accumulation, International Journal of Pharmaceutics 2025
6. Marwedel B., De May H., Anderson L., Medina L., Kennedy E., Flores E. O’Rourke J., Olewine M., Lagutina I., Fitzpatrick L., Shultz F., Kusewitt D., Bartee E., Adams S., Noureddine A., Serda R. TLR agonist nano immune therapy clears peritoneal and systemic ovarian cancer. Advanced Healthcare Materials 2024 14 (7), 2570042

 

 In Metabolic Diseases:

7. Mota L., Zhang D., Soto Ortiz Y., Zertuche Gonzalez F., Chung E., Dang C., Noureddine A., Brey E., Gonzalez Porras M., Integrin α7 defines a profibrotic adipose stromal population targeted for nanoparticle PAI-1 gene silencing in obesity, Molecular Therapy 2026
8. Zhang, D.; Tang, L.; Hipple, T.; Mowry, C.; Brinker, J.; Brey, E.; Noureddine, A.* and Gonzalez Porras M. Local administration of lipid-silica nanohybrid-carried forskolin modulates thermogenesis in human adipocytes and impedes weight gain in mice, Advanced Functional Materials 2024, 35 (11), 2404179