Seminar:

Although historically known for its malodorous rotten egg smell, hydrogen sulfide (H2S) is now accepted as an important physiological mediator and signaling agent, joining CO and NO as an endogenous gasotransmitter. In its recent emergence as an important biological molecule, investigations have already revealed diverse and important roles of H2S in many aspects of human health and disease, including diabetes, hypertension, inflammation, and neurodegeneration. Motivated by key challenges in understanding how H2S exerts its biological action, our group is developing new chemical tools for H2S detection and quantification, slow-releasing H2S donors, and bioorganic/bioinorganic models for studying H2S signaling. This presentation will focus on recent work from our group highlighting new chemical tools for H2S imaging and new insights obtained from model bioorganic and bioinorganic scaffolds.