William Sherman Garver

Research Professor

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Chemical Biology and Biochemistry

Contact Information

Email:
Phone: 505 277-6655
Office: Clark Hall Room 370

Education

  • B.A., Biological Chemistry and Molecular Biology, University of New Mexico, Albuquerque, NM.
  • M.S., Biological Chemistry and Molecular Biology, New Mexico State University, Las Cruces, NM.
  • Ph.D., Biological Chemistry and Molecular Biology, New Mexico State University, Las Cruces, NM.

Research

My research program investigates the molecular architecture, gene x modifying gene x nutrient interaction, and adaptive evolution of energy metabolism genes responsible for human health and disease. These studies have primarily focused on investigation of the Niemann-Pick C1 (NPC1) gene/protein which is ubiquitously expressed and serves as late endosome/lysosome lipid influx transporter that regulates cellular, tissue, and whole-body energy homeostasis. The NPC1 gene was originally mapped, cloned, and functionally characterized in relation to a rare childhood metabolic disease called Niemann-Pick C1 disease, but subsequently found to be associated with common adult obesity and/or type 2 diabetes resulting from several genome-wide association studies (GWAS). Most recently, the NPC1 protein was found to serve as the natural receptor for several species of filoviruses, including the Ebola and Marburg viruses that cause severe hemorrhagic fever and high mortality.           

Honors & Awards

  • Senior Fellow, Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA.
  • Research Assistant Professor and Lecturer, Division of Molecular Genetics, Department of Pediatrics, University of Arizona, Tucson, AZ.
  • Research Associate Professor and Senior Lecturer, Division of Molecular Genetics, Department of Pediatrics, University of Arizona, Tucson, AZ.
  • Research Professor and Principal Lecturer, Department of Chemistry and Chemical Biology, University of University of New Mexico, Albuquerque, NM.

Selected Publications

Select Original Research Articles

  • Garver WS, Heidenreich RA, Erickson RP, Thomas MA, Wilson JM. Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments. Journal of Lipid Research 41: 673-687, 2000.
  • Garver WS, Krishnan K, Gallagos JR, Michikawa M, Francis GA, Heidenreich RA. Niemann-Pick C1 protein regulates cholesterol transport to the trans-Golgi network and plasma membrane caveolae. Journal of Lipid Research 43: 579-589, 2002.
  • Garver WS, Xie C, Repa JJ, Turley SD, John M. Dietschy. Niemann-Pick C1 expression is not regulated by the amount of cholesterol flowing through cells in the mouse. Journal of Lipid Research 46: 1745-1754, 2005.
  • Garver WS, Jelinek D, Francis GA, Murphy BD. The Niemann-Pick C1 gene is downregulated by feedback inhibition of the SREBP pathway in human fibroblasts. Journal of Lipid Research 49: 1090-1102, 2008.
  • Garver WS, Jelinek D, Meaney FJ, Flynn J, Pettit KM, Shepherd G, Heidenreich RA, Walsh-Vockley CM, Castro G, Francis GA. The National Niemann-Pick type C1 disease database: Correlation of lipid profiles, mutations, and biochemical phenotypes. Journal of Lipid Research 51: 406-415, 2010.
  • Jelinek D, Millward V, Birdi A, Trouard TP, Heidenreich RA, Garver WS. NPC1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance. Human Molecular Genetics 20: 312-321, 2011.
  • Castillo JJ, Jelinek D, Gua H, Gannon NP, Vaughan RA, Horwood LJ, Meaney FJ, Garcia-Smith R, Trujillo KA, Heidenreich RA, Meyre D, Orlando RA, LeBoeuf RC, Garver WS. The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through regulation of central energy metabolism pathways. American Journal of Physiology 313: 183-194, 2017.
  • Castillo JJ, Hazlett ZS, Orlando RA, Garver WS. A global evolutionary and metabolic analysis of human obesity gene risk variants. Gene 627: 412-419, 2017.

 

Select Review Articles

  • Garver WS. Gene-diet interactions in childhood obesity. Current Genomics 12: 180-189, 2011.
  • Garver WS, Newman SB, Gonzales-Pacheco DM, Castillo JJ, Jelinek D, Heidenreich RA, Orlando RA. The genetics of childhood obesity and interaction with dietary macronutrients. Genes and Nutrition 8: 271-287, 2013.
  • Conn CA, Vaughan RA, Garver WS. Nutritional genetics and energy metabolism in human obesity. Current Nutrition Reports 2: 142-150, 2013.
  • Castillo JJ, Orlando RA, Garver WS. Gene-nutrient interactions and susceptibility to human obesity. Genes and Nutrition 12: 1-9, 2017.
  • Lamri A, Pigeyre M, Garver WS, Meyre D. The extending spectrum of NPC1-related human disorders: From Niemann-Pick C1 disease to obesity. Endocrine Reviews 39: 192-220, 2018.