Charles E. (Chad) Melancon III

Assistant Professor

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Chemical Biology and Biochemistry
Pharmaceutical Chemistry

Contact Information

Phone: 505-277-6655
Office: Clark Hall 349A


  • BS Biology, BA Chemistry, 2001, The University of New Orleans
  • PhD Biochemistry, 2006, The University of Texas at Austin
  • NIH Kirschstein Postdoctoral Fellow, 2007-2010, The Scripps Research Institute


  • Natural product genome mining and comparative genomics
  • Natural product drug discovery and chemical ecology
  • Natural product biosynthesis
  • Development of natural product detection systems
  • Development of novel strategies for manipulation of natural product biosynthetic pathways

Selected Publications

  • Guo, J.†;Melançon, C. E., III†; Lee, H. S.; Groff, D.; Schultz, P. G. Evolution of Amber Suppressor tRNAs for Efficient Bacterial Production of Proteins Containing Nonnatural Amino Acids. Ang. Chem. Int. Ed. 2009, 48, 9148-9151.
  • Thibodeaux, C. J.; Melançon, C. E., III; Liu, H.-w. Natural Product Sugar Biosynthesis and Enzymatic Glycodiversification. Ang. Chem. Int. Ed. 2008, 51, 9814-9859.
  • Zhang, H.; White, J. A.; Melançon, C. E., III; Kwon, H.-j.; Yu, W.-l.; Liu, H.-w. Elucidation of the Kijanimicin Gene Cluster: Insights into the Biosynthesis of Spirotetronate Antibiotics and Nitrosugars. J. Am. Chem. Soc. 2007, 129, 14670-14683.
  • Thibodeaux, C. J.; Melançon, C. E., III; Liu, H.-w. Unusual Sugar Biosynthesis and Natural Product Glycodiversification. Nature 2007, 446, 1008-1016.
  • Melançon, C. E., III; Liu, H.-w. Engineered Biosynthesis of Macrolide Derivatives Bearing the Non- Natural Deoxysugars 4-epi-D-Mycaminose and 3-N-Monomethylamino-3-Deoxy-D-Fucose. J. Am. Chem. Soc. 2007, 129, 4896-4897.