Abstract: Living systems produce a tremendous diversity of small molecules that have transformed society. These natural products serve as the basis for a wide array of chemical functions from drugs and pesticides to food preservatives and materials. Interestingly, although hundreds of thousands of natural products have been characterized to date, genome sequencing efforts of the past decade have revealed that the known set of natural products represents only a small fraction of nature’s biosynthetic potential. Our group is addressing the fundamental challenge of accelerating the rate of discovery and characterization of novel natural products and natural product-like compounds to expand the known chemical space of natural products that can be used to benefit society. To do so, we are developing methods to generate and screen millions of cyclic peptide natural product-like compounds and exploring the natural product repertoire of a genus of bacteria that has been relatively under-explored.

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Topic: Mark Walker Seminar

Time: Oct 23, 2020 04:00 PM Mountain Time (US and Canada)

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