Transitioning Organic Synthesis from Organic Solvents to Water: Following Nature's Lead
**Seminars begin at 4:00 PM and will be held in Clark Hall Room 101**
April 1, 2016
Three key reaction variables important to synthetic chemists include the reaction solvent, reaction temperature, and the choice of catalyst. The medium in which organic synthesis is performed is usually organic, while most reactions tend to require either heating or cooling. The catalyst typically involves a metal, and more often than not, is a precious metal such as palladium. This presentation will offer a win-‐win-‐win situation, addressing all of these issues from the standpoint of both economics and the environment. Several valued reactions in organic synthesis will be discussed that can be run in water, with most taking place at room temperature. Equally importantly, given that Pd is both costly and an endangered metal, these can now be effected using ppm levels of palladium, made possible by development of a new ligand, “HandaPhos”, enabled by its use in aqueous nanomicelles composed of a designer surfactant (e.g., TPGS-‐750-‐M or Nok). Unpublished work will focus on this new Pd chemistry, and will then shift to a complementary technology that involves new Fe-‐based nanoparticles applied to such cross-‐couplings and related reactions of considerable interest, especially to the pharmaceutical industry.