With ynamides emerging as a powerful and versatile building block for organic synthesis in recent years, its origin and a brief history in search for an atom-economical and efficient synthesis will be described. In addition, recent advances in methodological development utilizing ynamides will be presented.
Richard P. Hsung obtained his B.S. in chemistry and mathematics from Calvin College and attended The University of Chicago for his M.S. and Ph.D. degrees in organic chemistry with Professors Jeff Winkler and Bill Wulff, respectively. After postdoctoral stays with Professor Larry Sita in Chicago and Professor Gilbert Stork at Columbia University, he moved to University of Minnesota as an assistant professor in 1997. He was promoted to associate professor in 2002 and to full professor after moving to University of Wisconsin in 2006. He has coauthored over 250 publications and supervised over 150 students and postdoctoral fellows with research interests in developing stereoselective methods using allenamides, ynamides, enamides, and cyclic acetals and applications in natural product syntheses.