Department of Chemistry & Chemical Biology

MSC03 2060
300 Terrace St. NE
Albuquerque, NM 87131-0001

Physical Location:
Clark Hall

Phone: 505-277-6655


New Vistas in the Asymmetric Construction of C-C Bonds: Total Synthesis of Complex Bioactive Agents

September 7, 2018

Dr. P. Andrew Evans, Professor and Alfred R. Bader Chair of Organic Chemistry of Queen's University, Kingston, ON

Photo: Seminar:

Profile: Dr. P. Andrew Evans is the Alfred R. Bader Chair of Organic Chemistry and a Tier 1 Canada Research Chair in Organic and Organometallic Chemistry in the Department of Chemistry at Queen’s University. He received a B.Sc. with honors in Applied Chemistry at Newcastle Polytechnic in 1987 and a Ph.D. at the University of Cambridge in 1990 under the supervision of Andrew B. Holmes, FRS. He then completed postdoctoral studies with Philip D. Magnus, FRS, at the University of Texas at Austin as a NATO Postdoctoral Fellow. In 1993 he initiated his independent career at the University of Delaware, where he rose through the ranks to Professor before moving to Indiana University in 2001. In 2006, he moved to the University of Liverpool where he was the Heath Harrison Chair of Organic Chemistry before moving to his current position in July 2012. Recent awards include the ACS Cope Scholar Award, RSC Pedler Award, Royal Society Wolfson Research Merit Award, Pfizer Award for Creativity in Organic Chemistry, Johnson and Johnson Focused Giving Award, GlaxoWellcome Chemistry Scholar Award, Camille Dreyfus Teacher-Scholar Award, Eli Lilly Grantee Award and Zeneca Excellence in Chemistry Award. He has also served on ACS Division of Organic Chemistry as a Member-at-Large; Councilor, National Organic Symposium Executive Officer and Chair. Additionally, he has also served the Chem. Comm. Editorial Board and he is currently an Associate Editor for Synthesis and the new Editor-in-Chief for Organic Reactions. He has published more than 125 papers, articles, reviews, book chapters and monographs, in addition to delivering over 550 plenary and invited lectures.

Abstract: The seminar will describe the development and application of stereoselective transition metal-catalyzed cross-coupling and cycloaddition reactions for the total synthesis of bioactive agents.[1,2] Specifically, it will outline our approach to the construction of acyclic quaternary carbon stereogenic centers and to the development of a concise, efficient and scalable total synthesis of the complex bioactive sesquiterpene natural product, thapsigargin.[3] Hence, the first part will focus on a series of new metal-catalyzedallylic cross-coupling reactions with novel pronucleophiles[4,5] and the second part will outline the development of higher-order carbocyclization reactions that emulate terpene biosynthesis.[6]


  1. Oliver, S.; Evans, P. A. Synthesis 2013, 45, 3179.
  2. Inglesby, P. A.; Evans, P. A. Chem. Soc. Rev. 2010, 39, 2791.
  3. (a) Chen, D.; Evans, P. A. J. Am. Chem. Soc. 2017, 139, 6046.
  4. (a) Evans, P. A.; Oliver, S.; Chae, J. J. Am. Chem. Soc. 2012, 134, 19314. (b) Turnbull, B. W. H.; Oliver, S.; Evans, P. A. J. Am.Chem. Soc. 2015, 137, 15347. (c) Turnbull, B. W. H.; Chae, J.; Oliver, S.; Evans, P. A. Chem. Sci. 2017, 8, 4001.
  5. (a) Evans, P. A.; Clizbe, E. A.; Lawler, M. J.; Oliver, S. Chem. Sci. 2012, 3, 1835. (b) Turnbull, B. W. H.; Evans, P. A. J. Am.Chem. Soc. 2015, 137, 6156. (c) Wright, T. B.; Evans, P. A. J. Am. Chem. Soc. 2016, 138, 15303. (d) Wright, T. B.; Turnbull, B. W.H.; Evans, P. A. Submitted.
  6. (a) Evans, P. A.; Inglesby, P. A. J. Am. Chem. Soc. 2008, 130, 12838. (b) Evans, P. A.; Inglesby, P. A. J. Am. Chem. Soc. 2012, 134, 3635. (c) Mazumder, S.; Shang, D.; Negru, D. E.; Baik, M.-H.; Evans, P. A. J. Am. Chem. Soc. 2012, 134, 20569. (d) Inglesby, P.A.; Bacsa, J.; Negru, D. E.; Evans, P. A. Angew. Chem. Int. Ed. 2014, 53, 3952. (e) Evans, P. A.; Negru, D. E.; Shang, D. Angew.Chem. Int. Ed. 2015, 54, 4768.

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