Cyclodextrin-Based Polyvalent Systems: From Design to Applications

September 2, 2016

Dr. Chang-Chun Ling

Cyclodextrins (CDs) constitute a family of D-glucose-based host molecules with a hydrophobic cavity. They are known to form inclusion complexes with a wide range of organic molecules and have been used as excipients in drug formulations. The chemical modifications of CDs are challenging because of their polyhydroxyl functionalities. Over recent years, we have developed several efficient methodologies to chemically functionalize CDs. This has allowed us to develop different families of polyvalent systems based on CD scaffolds for various applications.  In this seminar, I will highlight our recent progress on methodology development to obtain multi-substituted CD hosts and some of the applications in biology such as inhibiting bacterial colonizations, studying weak carbohydrate-protein interactions and drug delivery.