Congratulation to John Latham

posted: Tue Jun 30 2015 13:49:55

John Latham, a former UNM Department of Chemistry and Chemical Biology graduate student from the Prof. Debra Dunaway-Mariano (DDM) Lab, has recently accepted an Assistant Professor position in the Department of Chemistry and Biochemistry at the University of Denver, in Denver, CO.  He will open his lab in the Fall of 2015.   The Latham Lab will study a unique class of radical-S-adenosyl methionine (RS) proteins that have recently been shown to modify ribosomally translated peptides to produce antibiotics, quorum sensors, and redox cofactors.   The RS proteins attributed to the modifying the peptides use a single [4Fe-4S] cluster to carry out the radical chemistry and multiple auxiliary [4Fe-4S] clusters with unknown functions.  The Latham Lab will employ traditional enzymology and biophysical techniques to study the structure-function relationship of select RS proteins from putative biosynthetic pathways found in pathogenic organisms.
While working the DDM Lab, John studied the chemical mechanism and physiological function of several hotdog-fold thioesterases among other pursuits.  After finishing his Ph.D. in 2012, he began his postdoctoral training at the University of California, Berkeley under Prof. Judith Klinman in the California Institute of Quantitative Biosciences (QB3).  At UC Berkeley he examined the biosynthetic pathway for the redox cofactor pyrroloquinoline quinone.